How much more does tirzepatide cost than semaglutide?

Across 323 reviewed providers with usable compounded injection quotes for both medicines, the median difference between their lowest published quotes is $67 per month. This is a within-provider price comparison, not matched maintenance doses or a verified bill.

Is compounded tirzepatide the same as Mounjaro or Zepbound?

No. Mounjaro and Zepbound are FDA-approved products from Eli Lilly. Compounded tirzepatide is prepared by a compounding pharmacy against a prescription and is not FDA-approved or reviewed for safety, efficacy or quality before dispensing. Some sellers list both; they are different products at different prices.

Which is better for weight loss, tirzepatide or semaglutide?

In the trial that compared them directly, tirzepatide produced greater average weight loss. Averages are not predictions for an individual, and side-effect tolerance often decides which drug someone can actually stay on. That is a conversation for a prescriber rather than a table.

Does the price go up as my tirzepatide dose increases?

At many sellers, yes. Tirzepatide titrates from 2.5 mg upward, and a seller that prices per milligram will charge more at each step. Sellers that hold one figure across the whole ladder are marked on this board, and over a year that policy is usually worth more than the starting price.

Can I switch from semaglutide to tirzepatide later?

Clinically that is a prescriber's call. Commercially it is much easier at a seller that already carries both molecules, since switching does not mean a new intake, a new consult and a new account. Sellers covering both are noted in each row.

How much more does tirzepatide cost than semaglutide?

Across 323 reviewed providers with usable compounded injection quotes for both medicines, the median difference between their lowest published quotes is $67 per month. This is a within-provider price comparison, not matched maintenance doses or a verified bill.

Is compounded tirzepatide the same as Mounjaro or Zepbound?

No. Mounjaro and Zepbound are FDA-approved products from Eli Lilly. Compounded tirzepatide is prepared by a compounding pharmacy against a prescription and is not FDA-approved or reviewed for safety, efficacy or quality before dispensing. Some sellers list both; they are different products at different prices.

Which is better for weight loss, tirzepatide or semaglutide?

In the trial that compared them directly, tirzepatide produced greater average weight loss. Averages are not predictions for an individual, and side-effect tolerance often decides which drug someone can actually stay on. That is a conversation for a prescriber rather than a table.

Does the price go up as my tirzepatide dose increases?

At many sellers, yes. Tirzepatide titrates from 2.5 mg upward, and a seller that prices per milligram will charge more at each step. Sellers that hold one figure across the whole ladder are marked on this board, and over a year that policy is usually worth more than the starting price.

Can I switch from semaglutide to tirzepatide later?

Clinically that is a prescriber's call. Commercially it is much easier at a seller that already carries both molecules, since switching does not mean a new intake, a new consult and a new account. Sellers covering both are noted in each row.

Tirzepatide, injected

Compounded Tirzepatide, Prices and Plans Compared

Compare tirzepatide injection prices, dose policies, and care options. Confirm the formulation, required payment, included services, and dispensing pharmacy before subscribing; a lower starting quote may come with different terms.

By Hana BrennanPricing & provider data

394 providers comparedReviewed against our editorial methodologyPartners listed firstUpdated October 2026

Disclosure: GLP Loss is reader-supported. Some links below are affiliate links — if you start care through them we may earn a commission, at no extra cost to you. Partners are listed first; a commission never changes what we write about a provider. How we make money.

Top 5 for compounded tirzepatide

Every seller here is a partner — we may earn from these links

SkinnyRxPartner
A tirzepatide price you can check
From
$299
Check availability
ShedPartner
Compounded pricing without a membership
From
$199
Check availability
Bodybuilding Health+Partner
A headline that is the monthly rate
From
$209
Check availability
RxSpan MDPartner
Comparing plan terms upfront
From
$329
Check availability
WellorithmPartner
Compounded injections and brand
From
$376
Check availability

The shortlist

394 providers, side by side

Partners appear first and are labeled; other providers follow the published rubric. Prices are scoped to the selected molecule and route. A dash means no usable quote is recorded; it does not mean free treatment or that a provider is expensive. Promotional or implausible figures are excluded from the displayed price. Confirm current product, fees, and payment terms with the provider.

Sort

Provider

Access

Dose price

Provider states

SkinnyRxPartner

A tirzepatide price you can check

Read review →

Access

From $299/mo

Dose price

—

Provider states

—

Check availability

ShedPartner

Compounded pricing without a membership

Read review →

Access

From $199/mo

Dose price

—

Provider states

—

Check availability

Bodybuilding Health+Partner

A headline that is the monthly rate

Read review →

Access

From $209/mo

Dose price

—

Provider states

—

Check availability

RxSpan MDPartner

Comparing plan terms upfront

Read review →

Access

From $329/mo

Dose price

—

Provider states

All 50

Check availability

WellorithmPartner

Compounded injections and brand

Read review →

Access

From $376/mo

Dose price

—

Provider states

Check availability

OakPartner

Month-by-month billing

Read review →

Access

From $300/mo

Dose price

Rises

Provider states

—

Check availability

GalaPartner

One price across both molecules

Read review →

Access

From $199/mo

Dose price

Flat

Provider states

All 50

Check availability

WillowPartner

Weighing the pill against the shot

Read review →

Access

From $399/mo

Dose price

—

Provider states

Check availability

EdenPartner

A price worth confirming in writing

Read review →

Access

From $298/mo

Dose price

Flat

Provider states

All 50

Check availability

HumeCare+Partner

Buyers titrating to high doses

Read review →

Access

From $299/mo

Dose price

—

Provider states

—

Check availability

YourEraPartner

A seller that states its own terms

Read review →

Access

From $159.20/mo

Dose price

Flat

Provider states

—

Check availability

Direct MedsPartner

One figure that covers everything

Read review →

Access

From $399/mo

Dose price

—

Provider states

—

Check availability

Belle HealthPartner

Reading which rung is monthly

Read review →

Access

From $249/mo

Dose price

Flat

Provider states

All 50

Check availability

FoundPartner

One price for either molecule

Read review →

Access

From $169/mo

Dose price

—

Provider states

All 50

Check availability

Sprout HealthPartner

Buyers taking six months upfront

Read review →

Access

From $378/mo

Dose price

—

Provider states

Check availability

CoreAge RxPartner

Flat pricing on either molecule

Read review →

Access

From $149/mo

Dose price

Flat

Provider states

All 50

Check availability

HealthRXPartner

Buyers committing to a year

Read review →

Access

From $214/mo

Dose price

Flat

Provider states

—

Check availability

MEDGmPartner

Monthly price not established

Read review →

Access

Price unconfirmed

Dose price

—

Provider states

All 50 + DC

Check availability

bmiMDPartner

A narrow gap between molecules

Read review →

Access

From $139/mo

Dose price

Flat

Provider states

All 50

Check availability

CollectivePartner

Year-long cost-led buyers

Read review →

Access

From $86/mo

Dose price

Flat

Provider states

—

Check availability

We never show a fabricated price or rating. Facts are shown only where a provider publishes them.

State counts describe provider-wide service areas. Confirm availability for your medication and location.

How this board is built

Among 323 reviewed providers with usable compounded injection quotes for both medicines, the median difference between their lowest tirzepatide and semaglutide quotes is $67 per month. This compares like formulations within each provider, but not matched maintenance doses or verified checkout totals. Read the dose and payment terms before deciding what the difference means for your treatment.

Some sellers list both a compounded and a brand-name price for tirzepatide. Those are different products — Zepbound dispensed as the manufacturer’s pen is not the same thing as a compounded vial — and this board ranks the compounded figure. Comparing one against the other produces a number that describes neither.

Why tirzepatide costs more, and when the gap is worth it

Tirzepatide acts on two receptors where semaglutide acts on one, and in the head-to-head trial it produced greater average weight loss. Those findings concern the approved trial products; they do not explain a particular seller’s pricing or verify a compounded vial.

What the price difference does not tell you is which will work better for you specifically. Trial averages are averages; response varies widely, and tolerability matters as much as potency for anyone who has to stay on a drug long enough to benefit.

The practical question is whether a seller lets you switch without starting over. A seller carrying both molecules on one intake means a change of plan is a conversation rather than a new account, a new consult, and a new set of shipping delays.

How we judge sellers

Price transparency — Can you find what a month costs — for the molecule and the form you want — before creating an account, and does the seller's own site agree with itself?
Honest headline — Is the figure the seller leads with the figure it bills? A price that needs a twelve-month prepay, or that is struck through from an anchor nobody pays, is a different number from a standing monthly rate.
Dose-ladder pricing — Does the price hold as your dose escalates, or is it re-set at every step? This is the difference most buyers only discover in month three.
Access — How many states the seller ships to, and whether it covers more than one molecule or delivery form.

We never show a fabricated price or rating, and access notes appear only where a provider publishes them. Pricing and availability change often — confirm current details on the provider’s own site.

Keep comparing

Compounded semaglutide, ranked · The lowest published monthly prices · Sellers that hold one price across doses · How we score sellers

Common questions

How much more does tirzepatide cost than semaglutide?: Across 323 reviewed providers with usable compounded injection quotes for both medicines, the median difference between their lowest published quotes is $67 per month. This is a within-provider price comparison, not matched maintenance doses or a verified bill.
Is compounded tirzepatide the same as Mounjaro or Zepbound?: No. Mounjaro and Zepbound are FDA-approved products from Eli Lilly. Compounded tirzepatide is prepared by a compounding pharmacy against a prescription and is not FDA-approved or reviewed for safety, efficacy or quality before dispensing. Some sellers list both; they are different products at different prices.
Which is better for weight loss, tirzepatide or semaglutide?: In the trial that compared them directly, tirzepatide produced greater average weight loss. Averages are not predictions for an individual, and side-effect tolerance often decides which drug someone can actually stay on. That is a conversation for a prescriber rather than a table.
Does the price go up as my tirzepatide dose increases?: At many sellers, yes. Tirzepatide titrates from 2.5 mg upward, and a seller that prices per milligram will charge more at each step. Sellers that hold one figure across the whole ladder are marked on this board, and over a year that policy is usually worth more than the starting price.
Can I switch from semaglutide to tirzepatide later?: Clinically that is a prescriber's call. Commercially it is much easier at a seller that already carries both molecules, since switching does not mean a new intake, a new consult and a new account. Sellers covering both are noted in each row.