Is Rx.com $146 a month?

Only on the six-month plan, and only as an average: the actual charge is $875 in one payment. The one-month rung is $175. Because the fill is four weeks rather than a calendar month, thirteen of them fall in a year, so even $175 understates what twelve months of treatment costs.

Does the price go up as my dose goes up?

No, and Rx.com is specific about it. Semaglutide runs 0.25 mg to 2.4 mg and tirzepatide 2.5 mg to 15 mg, and the price is the same at every step. That matters more than it sounds: dose-tiered pricing elsewhere routinely doubles a headline figure by month four.

Which pharmacy actually makes the medication?

Manifest Pharmacy, 1018 S. Batesville Road, Greer, South Carolina, named in the footer of the pricing page. The provider network is MD Integrations. Naming both is what lets a buyer check either one independently, against state licensing records or a warning-letter search.

Why do two pages show different prices?

Rx.com runs a current plan-selector page quoting $175, $495 and $875 for semaglutide, and an older program page quoting $179.99 for a first month and $279.99 a month after. The second is still live and is the page the first one links to for the full FAQ. Confirm which schedule applies at checkout before paying.

Rx.com is a GLP-1 sellers by price service. Its stated availability: 49 states (all except Alaska). It displays a LegitScript certification claim, which we record as a claim and not as a verified fact: LegitScript's public checker is gated and returns the same page for any domain put into it, so no one can reproduce a check from it. What our record does not establish: whether it bills insurance and how its intake works. Ask for those in writing before you pay.

Is Rx.com expensive compared with other GLP-1 sellers by price providers?

Rx.com publishes a starting figure of $190/mo. Across the 263 GLP-1 sellers by price providers we review that publish a single monthly figure, those run $76 to $449 with a median of $179, which puts Rx.com above the median. The other 14 GLP-1 sellers by price providers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.

Updated September 2026

Rx.com review

Pharmacy named, doses published

Every rung of the plan ladder is printed, the dispensing pharmacy is named and the milligram range is published — and the month being sold is twenty-eight days long.

Our verdict

Rx.com names Manifest Pharmacy as the dispenser and MD Integrations as the provider network, publishes the milligram range each price covers, holds the price flat across that range, and prints all six plan rungs side by side. The defect is the unit: a fill is four weeks and billing continues every twenty-eight days, so thirteen of them land in a calendar year and the one-month figure buys less month than it says. The larger problem is a second live page, the one this page's own footnote sends readers to for the full program FAQ. It publishes a different schedule entirely, at $179.99 for a first month and $279.99 a month after it. Two published ongoing rates for the same drug is not something a buyer can resolve from outside.

Disclosure: GLP Loss is reader-supported. Some links below are affiliate links — if you start care through them we may earn a commission, at no extra cost to you. The order on this page is not commercial, and a commission never changes what we write about a provider. How we make money.

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At a glance

Category: GLP-1 pricing
Molecule: Semaglutide · Tirzepatide
Form: Injection
Dose pricing: Flat across doses
States: 49
From: $190/mo
Dose published: Yes
Prescription: Required
Compounded: Yes — not FDA-approved
Pharmacy: Named
Availability: 49 states (all except Alaska)
LegitScript: Claimed by provider
Updated: September 2026

What it is

A prescription marketplace operating its own GLP-1 weight loss program, selling compounded semaglutide and tirzepatide on one, three and six-month plans with the provider visit, supplies and cold shipping included.

How it works

A confidential online questionnaire and a photo ID, with a short video visit added in some states, reviewed by a licensed provider in the buyer's state, usually within twenty-four hours. Nothing is charged for medication if the provider does not prescribe. Plans do not auto-renew; a care team check-in precedes every refill.

Pricing transparency

Semaglutide is $175 for one month, $495 for three ($165 a month) and $875 for six ($146 a month); tirzepatide is $285, $795 ($265 a month) and $1,550 ($259 a month). Each is a single upfront payment. Rx.com states there is no membership fee, no separate medication bill and no dose upcharge. The fill is a four-week supply and billing continues every twenty-eight days, so the one-month rate covers roughly $190 of calendar month for semaglutide and $309 for tirzepatide. A separate live page publishes the program as $179.99 then $279.99 a month for compounded semaglutide, and $279.99 then $379.99 for tirzepatide.

Branded vs compounded

Compounded semaglutide at 0.25 mg to 2.4 mg and compounded tirzepatide at 2.5 mg to 15 mg, at one price across the whole range. Compounded drugs are not FDA-approved and are not reviewed by the FDA for safety, efficacy or quality before dispensing, which Rx.com repeats on every pricing surface. Medication is dispensed by Manifest Pharmacy of Greer, South Carolina, and the site carries LegitScript certification.

Pros and watch-outs

What we like

The dispensing pharmacy and the provider network are both named
The milligram range each price covers is published, and the price is flat across it
All six plan rungs are shown together rather than one headline figure
No membership fee, no automatic renewal and no charge if not prescribed

Watch-outs

A fill is four weeks, billed every twenty-eight days, and sold as a month
A second live page publishes a completely different ongoing rate
Reaching the low per-month rate means paying $875 or $1,550 upfront
Medication sales are final; nothing can be returned once shipped

Best for

Buyers who want the pharmacy, the dose and every rung stated.

Who should look elsewhere

Anyone unwilling to pay six months in one charge to reach the low rate.

How Rx.com compares

A few alternatives worth a look, depending on what you’re optimizing for.

SkinnyRx
A tirzepatide price you can check
See SkinnyRx →
Bodybuilding Health+
A headline that is the monthly rate
See Bodybuilding Health+ →
Synergy Rx
Compounded and branded together
See Synergy Rx →

Compare all providers side by side →

More GLP-1 sellers by price reviews: NouriNovaNoviNovoCare PharmacyNowPatientNuBloom

Owen Castellanos

Evidence & trials · Reviewed and last verified September 2026

How we assessed this. This review reflects GLP Loss’s own read of Rx.com’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.

Frequently asked

Is Rx.com $146 a month?: Only on the six-month plan, and only as an average: the actual charge is $875 in one payment. The one-month rung is $175. Because the fill is four weeks rather than a calendar month, thirteen of them fall in a year, so even $175 understates what twelve months of treatment costs.
Does the price go up as my dose goes up?: No, and Rx.com is specific about it. Semaglutide runs 0.25 mg to 2.4 mg and tirzepatide 2.5 mg to 15 mg, and the price is the same at every step. That matters more than it sounds: dose-tiered pricing elsewhere routinely doubles a headline figure by month four.
Which pharmacy actually makes the medication?: Manifest Pharmacy, 1018 S. Batesville Road, Greer, South Carolina, named in the footer of the pricing page. The provider network is MD Integrations. Naming both is what lets a buyer check either one independently, against state licensing records or a warning-letter search.
Why do two pages show different prices?: Rx.com runs a current plan-selector page quoting $175, $495 and $875 for semaglutide, and an older program page quoting $179.99 for a first month and $279.99 a month after. The second is still live and is the page the first one links to for the full FAQ. Confirm which schedule applies at checkout before paying.
Is Rx.com legit?: Rx.com is a GLP-1 sellers by price service. Its stated availability: 49 states (all except Alaska). It displays a LegitScript certification claim, which we record as a claim and not as a verified fact: LegitScript's public checker is gated and returns the same page for any domain put into it, so no one can reproduce a check from it. What our record does not establish: whether it bills insurance and how its intake works. Ask for those in writing before you pay.
Is Rx.com expensive compared with other GLP-1 sellers by price providers?: Rx.com publishes a starting figure of $190/mo. Across the 263 GLP-1 sellers by price providers we review that publish a single monthly figure, those run $76 to $449 with a median of $179, which puts Rx.com above the median. The other 14 GLP-1 sellers by price providers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.

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