Does Signos actually prescribe a GLP-1?

Yes, though not directly. Clinical services run through OpenLoop Health and other independent U.S.-licensed clinician networks, and Signos states that it does not manufacture, compound, dispense or distribute any medication. Medication cost is included in the program price. Signos itself remains a technology and wellness platform.

Is $199 a monthly price?

It is a four-week price. Signos defines its plan lengths in weeks and labels them in months, so the plan sold as six months is twenty-four weeks long. A year of treatment is thirteen of those cycles rather than twelve, which puts the true calendar cost above the advertised figure.

What does $199 buy compared with $276?

$199 a cycle is the microdose tier on the twenty-four-week plan, for either molecule. Standard compounded tirzepatide is $276 on the same term and $329 on the twelve-week term; standard semaglutide is $219 and $249. The gap between the microdose and standard tiers is the largest single variable in what a Signos plan costs.

Can the monitor be bought without medication?

Yes. The CGM plans run $169, $199 and $299 a month for six-, three- and one-month terms, medication excluded. There is also GLP-1 Essentials at $89 a month across six months — six fifteen-day sensors for someone already on a GLP-1 elsewhere, with the medication explicitly not included.

Is Signos expensive compared with other GLP-1 sellers by price providers?

Signos publishes a starting figure of $216/mo. Across the 306 GLP-1 sellers by price providers we review that publish a single monthly figure, those run $76 to $449 with a median of $179, which puts Signos above the median. The other 20 GLP-1 sellers by price providers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.

Updated September 2026

Signos review

Glucose monitor bundled

The $199 rate covers four weeks, not a calendar month, and the plan Signos calls six months runs twenty-four weeks.

Our verdict

Signos is a continuous glucose monitoring company first, and the GLP-1 program is built on top of that rather than beside it — the Dexcom Stelo sensor and the medication arrive on one bill. The pricing carries two distortions worth naming. Signos labels its plans in months while defining them in weeks, so a six-month plan is twenty-four weeks and $199 buys four weeks rather than a calendar month. And the figure struck through beside $199 is $219, which is not a withdrawn price but the live rate on the twelve-week plan.

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At a glance

Category: GLP-1 pricing
Molecule: Semaglutide · Tirzepatide
Form: Injection
From: $199 per 4 weeks
Dose published: No
Prescription: Required
Compounded: Yes — not FDA-approved
Pharmacy: Not named
Updated: September 2026

What it is

A metabolic health platform selling a Dexcom Stelo continuous glucose monitor with an AI app, which now bundles compounded GLP-1 medication prescribed through OpenLoop Health and other independent clinician networks.

How it works

An intake survey reviewed asynchronously by a licensed clinician, with no scheduled video visit. Signos does not employ the prescribers, does not compound, dispense or distribute medication, and states that the clinicians retain full discretion to prescribe or decline. Products are split into a microdose tier and a standard tier, and the survey routes a patient to one of them based on the stated weight goal.

Pricing transparency

The GLP-1 plans price per four-week cycle on a fixed commitment. Microdose semaglutide and microdose tirzepatide are $199 a cycle across twenty-four weeks or $219 across twelve. Standard semaglutide is $219 and $249 on the same two terms; standard tirzepatide is $276 and $329. Paid up front those are $1,194, $1,314 and $1,656 for twenty-four weeks. Medication, the sensors and the app are inside the price. The monitor alone is sold separately at $169, $199 and $299 a month by term, and a part-time GLP-1 Essentials kit for people already medicated is $89 a month for six months with no medication.

Branded vs compounded

Compounded semaglutide and compounded tirzepatide, injectable, in a microdose and a standard tier. Compounded drugs are not FDA-approved and are not reviewed by the FDA for safety, efficacy or quality before dispensing, and Signos states this directly. No milligram strength is published for either tier, so microdose and standard describe the dosing as fully as anything on the site does before the clinician review.

Pros and watch-outs

What we like

A Dexcom Stelo sensor and the medication arrive on one bill
Four separate products are priced rather than one headline figure
The clinician network and its independence are named outright
Compounded status is disclosed in the seller's own words

Watch-outs

A plan month is four weeks, so a year costs thirteen of them
The struck-through figure is the shorter plan's live rate
No milligram dose separates the microdose and standard tiers
The $199 rate requires a twenty-four-week commitment

Best for

Buyers who want glucose data alongside the drug.

Who should look elsewhere

Anyone needing a month-to-month GLP-1 plan.

How Signos compares

A few alternatives worth a look, depending on what you’re optimizing for.

SkinnyRx
A tirzepatide price you can check
See SkinnyRx →
Bodybuilding Health+
A headline that is the monthly rate
See Bodybuilding Health+ →
Synergy Rx
Compounded and branded together
See Synergy Rx →

Compare all providers side by side →

More GLP-1 sellers by price reviews: Transparent MedsTrellis VitalityTrillium MedsTrimRxTrinity Medstru Weight Loss

Hana Brennan

Pricing & provider data · Reviewed and last verified September 2026

How we assessed this. This review reflects GLP Loss’s own read of Signos’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.

Frequently asked

Does Signos actually prescribe a GLP-1?: Yes, though not directly. Clinical services run through OpenLoop Health and other independent U.S.-licensed clinician networks, and Signos states that it does not manufacture, compound, dispense or distribute any medication. Medication cost is included in the program price. Signos itself remains a technology and wellness platform.
Is $199 a monthly price?: It is a four-week price. Signos defines its plan lengths in weeks and labels them in months, so the plan sold as six months is twenty-four weeks long. A year of treatment is thirteen of those cycles rather than twelve, which puts the true calendar cost above the advertised figure.
What does $199 buy compared with $276?: $199 a cycle is the microdose tier on the twenty-four-week plan, for either molecule. Standard compounded tirzepatide is $276 on the same term and $329 on the twelve-week term; standard semaglutide is $219 and $249. The gap between the microdose and standard tiers is the largest single variable in what a Signos plan costs.
Can the monitor be bought without medication?: Yes. The CGM plans run $169, $199 and $299 a month for six-, three- and one-month terms, medication excluded. There is also GLP-1 Essentials at $89 a month across six months — six fifteen-day sensors for someone already on a GLP-1 elsewhere, with the medication explicitly not included.
Is Signos expensive compared with other GLP-1 sellers by price providers?: Signos publishes a starting figure of $216/mo. Across the 306 GLP-1 sellers by price providers we review that publish a single monthly figure, those run $76 to $449 with a median of $179, which puts Signos above the median. The other 20 GLP-1 sellers by price providers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.

Check availability →

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