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GLP Loss

Independent · GLP-1 only

GLP-1, pricedand ranked by whatthe evidence supports.

Independent reviews of GLP-1 telehealth sellers — semaglutide and tirzepatide, compounded and brand — with the real monthly cost walked to checkout, not the advertised teaser.

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Scores are computed from a published rubric and never move with who pays us. The option we rate best on evidence is one we earn nothing from — and we say so on the page.

semaglutide

Compounded Semaglutide

The advertised figure is almost never the monthly charge. We walk each seller's intake to the payment screen and publish what it actually asks for.

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Compounded Tirzepatide

Some sellers hold one price across every dose; others re-price you at each titration step. That difference is worth more over a year than the headline gap between them.

Explore →oral

Pills & Oral

Oral GLP-1s are sold as the cheaper route and priced by the same sellers as the injection. Sometimes they cost more. We price both from the same checkout.

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Latest research

All research →
What actually differsReviewed by the FDA before saleBrand onlyManufacturing inspected to the same standardBrand onlyStudied in the pivotal trialsBrand onlyRequires a prescriptionBothDispensed by a licensed pharmacyBothPrice published openlyUsually compounded
Safety

Compounded vs Brand-Name GLP-1: What Actually Differs

Compounded semaglutide is not a generic Wegovy. It is a preparation no agency has reviewed for safety, efficacy or quality before it reaches you.

Most commonly reported effects, pivotal obesity trialsNauseaup to 44%Diarrheaup to 30%Vomitingup to 24%Constipationup to 24%Mostly mild to moderate, mostly during dose escalation. Placebo groups reported the same effects at lower rates.
Safety

GLP-1 Side Effects: What the Trials Recorded

Nausea and diarrhea lead, mostly during dose escalation, mostly mild to moderate — and between 4% and 7% of trial participants stopped because of them.

Mean weight change, separate trials, not a head-to-headSemaglutide 2.4 mg, 68 weeks−14.9%Tirzepatide 5 mg, 72 weeks−15.0%Tirzepatide 10 mg, 72 weeks−19.5%Tirzepatide 15 mg, 72 weeks−20.9%STEP 1 and SURMOUNT-1 enrolled different people over different durations. Read as context, never as a race.
Evidence

Tirzepatide vs Semaglutide: What the Trials Actually Measured

Tirzepatide produced larger average weight loss in its own trial, but the only randomized head-to-head between the two was run in type 2 diabetes at a half-dose of semaglutide.

The GLP Loss standard

The only placebo-controlled adult trial behind GLP-1 is 29 years old, n=19, and never replicated. We say so, on the pages that sell it.

A rank is an output

Scores are computed from a published rubric — evidence, price transparency, value, ordering experience, clinical support. No provider carries a score we typed in by hand.

Blind to who pays

The scoring function does not read commercial status. Partners are shown first and labeled as such; that is display order, and it never touches the number.

Prices read from the seller

Every price on this site was read off the provider's own page, not a program description. The two disagree more often than you would expect.

Where to start

Vetted ways to actually get care.

We rank providers on evidence and transparency. Commercial relationships set the order of partners — never the verdict.

Disclosure: GLP Loss is reader-supported, and some pages carry affiliate links. We earn nothing from the links on this page — what appears here is not affected by what pays. How we make money.